Isotonix OPC-3 Improves Circulation and helps Diabetes

Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavonoid Formula OPC-3®

Maria R. Cesarone, MD



Department of Biomedical Science, G D'Annunzio University Chieti, Pescara, Italy



Andrea Di Renzo



Department of Biomedical Science, G D'Annunzio University Chieti, Pescara, Italy



Silvia Errichi, MD



Frank Schönlau, PhD



Horphag Research UK, London, United Kingdom



James L. Wilmer, PhD



nutraMetrix®, Division of Market America, Greensboro, North Carolina



Julian Blumenfeld, MD



nutraMetrix®, Division of Market America, Greensboro, North Carolina,



A new study at the Department of Biomedical Science in Pescara, Italy found that Isotonix OPC-3 lowered cadiovascular risk factors in a test group of 61 individuals. The researchers found that "All major cardiovascular risk factors were improved with blood pressure, total cholesterol, and fasting blood glucose lowered.



This study investigated the efficacy of isotonic bioflavonoid supplementation, OPC-3 on 61 individuals presenting with risk factors meeting the criteria for metabolic syndrome. Subjects were supplemented with a proprietary isotonic bioflavonoid OPC-3 or placebo over 2 months. Plasma oxidative stress status was significantly lowered by 10.1% with OPC-3. All major cardiovascular risk factors were improved with blood pressure, total cholesterol, and fasting blood glucose lowered. OPC-3 significantly improved endothelial function as evaluated by increased vasorelaxation in reactive hyperemia and enhanced diastolic carotid artery flow. Cardiac ultrasound scanning revealed a significant increase of left ventricular ejection fraction. Skin microcirculation was enhanced, and better tissue perfusion led to significantly increased transcutaneous oxygen partial pressure and decreased pCO2. With OPC-3 a dramatic and significant plasma C-reactive protein decrease by 52.1% occurred. Individuals may improve key cardiovascular risk factors by daily supplementation with the bioflavonoid OPC-3 as an important part of a healthier lifestyle.

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